TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - van Heuvel, Yasemin
A1  - Schatz, Stefanie
A1  - Rosengarten, Jamila Franca
A1  - Stitz, Jörn
T1  - Infectious RNA: Human Immunodeficiency Virus (HIV) Biology, Therapeutic Intervention, and the Quest for a Vaccine
JF  - Toxins
N2  - Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected host cell factors to enable virus replication. The viral genomic RNA of the human immunodeficiency virus (HIV) encompasses nine genes encoding in less than 10 kb all proteins needed for replication in susceptible host cells. To do so, the genomic RNA undergoes complex alternative splicing to facilitate the synthesis of the structural, accessory, and regulatory proteins. However, HIV strongly relies on the host cell machinery recruiting cellular factors to complete its replication cycle. Antiretroviral therapy (ART) targets different steps in the cycle, preventing disease progression to the acquired immunodeficiency syndrome (AIDS). The comprehension of the host immune system interaction with the virus has fostered the development of a variety of vaccine platforms. Despite encouraging provisional results in vaccine trials, no effective vaccine has been developed, yet. However, novel promising vaccine platforms are currently under investigation.
KW  - Retroviren
KW  - Retroviruses
KW  - HIV
KW  - Virus Replication
KW  - mRNA Splicing
KW  - Antiretroviral Therapy (ART)
KW  - HIV Vaccines
KW  - HIV
KW  - Antiretrovirale Substanz
Y1  - 2022
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:832-epub4-19595
SN  - 2072-6651
SS  - 2072-6651
U6  - https://doi.org/10.3390/toxins14020138
DO  - https://doi.org/10.3390/toxins14020138
VL  - 14
IS  - 2
SP  - 26
S1  - 26
PB  - MDPI
ER  -