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Synthesis of (−)‐menthol: Industrial synthesis routes and recent development

  • Abstract (−)‐Menthol is one of the most popular aroma compounds worldwide. While in the past mostly extracted from mint plants, today (−)‐menthol synthesis from other raw materials is becoming more relevant. Common starting materials for menthol synthesis are m‐cresol, citral and myrcene, but also substrates like menthone, mono‐ and bicyclic terpenes and terpenoids have been used for this purpose in the past. As for many applications (−)‐menthol of high purity is required, asymmetric syntheses and enantiomeric resolution of obtained raw products are applied for menthol production. This review gives an overview on the most important synthetic menthol production processes of the companies Symrise, Takasago and BASF and relevant literature in the field of menthol synthesis with a focus on the last 20 years.

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Author:Dominik Dylong, Peter J. C. Hausoul, Regina Palkovits, Matthias Eisenacher
Parent Title (English):Flavour and Fragrance Journal
Document Type:Article
Date of first Publication:2022/06/12
Date of Publication (online):2022/11/08
Tag:Asymmetric Catalysis; Industrial Chemistry; Menthol; Teterogeneous Catalysis
Page Number:15
Institutes:Angewandte Naturwissenschaften (F11)
Dewey Decimal Classification:500 Naturwissenschaften und Mathematik
Open Access:Open Access
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International