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Emergency management services, such as firefighting, rescue teams and ambulances,are all heavily reliant on road networks. However, even for highly industrialised countries such asGermany, and even for large cities, spatial planning tools are lacking for road network interruptionsof emergency services. Moreover, dependencies of emergency management expand not only onroads but on many other systemic interrelations, such as blockages of bridges. The first challenge thispaper addresses is the development of a novel assessment that captures systemic interrelations ofcritical services and their dependencies explicitly designed to the needs of the emergency services.This aligns with a second challenge: capturing system nodes and areas around road networksand their geographical interrelation. System nodes, road links and city areas are integrated into aspatial grid of tessellated hexagons (also referred to as tiles) with geographical information systems.The hexagonal grid is designed to provide a simple map visualisation for emergency planners andfire brigades. Travel time planning is then optimised for accessing city areas in need by weighingimpaired areas of past events based on operational incidents. The model is developed and testedwith official incident data for the city of Cologne, Germany, and will help emergency managers tobetter device planning of resources based on this novel identification method of critical areas.
Potential analyses identify possible locations for renewable energy installations, such as wind turbines and photovoltaic arrays. The results of previous potential studies for Germany, however, are not consistent due to different assumptions, methods, and datasets being used. For example, different land-use datasets are applied in the literature to identify suitable areas for technologies requiring open land. For the first time, commonly used datasets are compared regarding the area and position of identified features to analyze their impact on potential analyses. It is shown that the use of Corine Land Cover is not recommended as it leads to potential area overestimation in a typical wind potential analyses by a factor of 4.7 and 5.2 in comparison to Basis-DLM and Open Street Map, respectively. Furthermore, we develop scenarios for onshore wind, offshore wind, and open-field photovoltaic potential estimations based on land-eligibility analyses using the land-use datasets that were proven to be best by our pre-analysis. Moreover, we calculate the rooftop photovoltaic potential using 3D building data nationwide for the first time. The potentials have a high sensitivity towards exclusion conditions, which are also currently discussed in public. For example, if restrictive exclusions are chosen for the onshore wind analysis the necessary potential for climate neutrality cannot be met. The potential capacities and possible locations are published for all administrative levels in Germany in the freely accessible database (Tool for Renewable Energy Potentials—Database), for example, to be incorporated into energy system models.
Campylobacter spp. are one of the most important food-borne pathogens, which are quite susceptible to environmental or technological stressors compared to other zoonotic bacteria. This might be due to the lack of many stress response mechanisms described in other bacteria. Nevertheless, Campylobacter is able to survive in the environment and food products. Although some aspects of the heat stress response in Campylobacter jejuni are already known, information about the stress response in other Campylobacter species are still scarce. In this study, the stress response of Campylobacter coli and Campylobacter lari to elevated temperatures (46°C) was investigated by survival assays and whole transcriptome analysis. None of the strains survived at 46°C for more than 8 h and approximately 20% of the genes of C. coli RM2228 and C. lari RM2100 were differentially expressed. The transcriptomic profiles showed enhanced gene expression of several chaperones like dnaK, groES, groEL, and clpB in both strains, indicating a general involvement in the heat stress response within the Campylobacter species. However, the pronounced differences in the expression pattern between C. coli and C. lari suggest that stress response mechanisms described for one Campylobacter species might be not necessarily transferable to other Campylobacter species.
Kompetenzen auf dem Gebiet der Datenbanken gehören zum Pflichtbereich der Informatik. Das Angebot an Lehrbüchern, Vorlesungsformaten und Tools lässt sich jedoch für Lehrende oft nur eingeschränkt in die eigene Lehre integrieren. In diesem Aufsatz schildern wir unsere Erfahrungen in der Nutzung (frei) verfügbarer und der Entwicklung eigener digitaler Inhalte für grundlegende Datenbankveranstaltungen. Die Präferenzen der Studierenden werden mittels Nutzungsanalysen und Befragungen ermittelt. Wir stellen die Anforderungen auf, wie die nicht selten aufwendig herzustellenden digitalen Materialien von Lehrenden in ihre Lehr- und Lernumgebungen integriert werden können. Als konstruktive Antwort auf diese Herausforderung wird das Konzept EILD zur Entwicklung von Inhalten für die Lehre im Fach Datenbanken vorgestellt. Die Inhalte sollen in vielfältigen Lernszenarien eingesetzt werden können und mit einer Creative Commons (CC) Lizenzierung als OER (open educational resources) frei zur Verfügung stehen.
Anaerobic digestion plants have the potential to produce biogas on demand to help balance renewable energy production and energy demand by consumers. A proportional integral (PI) controller is constructed and tuned with a novel tuning method to control biogas production in an optimal manner. In this approach, the proportional part of the controller is a function of the feeding rate and system's degree of stability. To estimate the degree of stability, a simulation‐based soft sensor is developed. By means of the PI controller, the requirement for gas storage capacity of the digester is reduced by approximately 30 % compared to a constant, continuous feeding regime of the digester.
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a requirement for successful therapy, which is frequently not possible due to the lack of suitable dosage forms. For precision medicine, individual characteristics of patients are considered for the selection of the best possible API in the most suitable dose with the most effective release profile to improve therapeutic outcome. 3d printing is inherently suitable for manufacturing of individualized medicines with varying dosages, sizes, release profiles and drug combinations in small batch sizes, which cannot be manufactured with traditional technologies. However, understanding of critical quality attributes and process parameters still needs to be significantly improved for this new technology. To ensure health and safety of patients, cleaning and process validation needs to be established. Additionally, adequate analytical methods for the in-process control of intermediates, regarding their printability as well as control of the final 3d printed tablets considering any risk of this new technology will be required. The PolyPrint consortium is actively working on developing novel polymers for fused deposition modeling (FDM) 3d printing, filament formulation and manufacturing development as well as optimization of the printing process, and the design of a GMP-capable FDM 3d printer. In this manuscript, the consortium shares its views on quality aspects and measures for 3d printing from drug-loaded filaments, including formulation development, the printing process, and the printed dosage forms. Additionally, engineering approaches for quality assurance during the printing process and for the final dosage form will be presented together with considerations for a GMP-capable printer design.
We examine the impact of the existence on an explicit deposit insurance (DI) scheme and its design features on bilateral cross‐border deposits (CBD) in a gravity model setting. We find that both the absolute quality of a country's DI and its relative quality vis‐à‐vis other countries' DI generally affect depositor behavior. However, during systemic banking crises, cross‐border depositors primarily seek countries with the best DI schemes. Similarly, during the 2008–2009 great financial crisis, the emergency actions taken by the governments, which supply and maintain these safe havens, have led to substantial relocations of CBD. (JEL F34, G18)
In Latin America and the Caribbean, river restoration projects are increasing, but many lack strategic planning and monitoring. We tested the applicability of a rapid visual social–ecological stream assessment method for restoration planning, complemented by a citizen survey on perceptions and uses of blue and green infrastructure. We applied the method at three urban streams in Jarabacoa (Dominican Republic) to identify and prioritize preferred areas for nature-based solutions. The method provides spatially explicit information for strategic river restoration planning, and its efficiency makes it suitable for use in data-poor contexts. It identifies well-preserved, moderately altered, and critically impaired areas regarding their hydromorphological and socio-cultural conditions, as well as demands on green and blue infrastructure. The transferability of the method can be improved by defining reference states for assessing the hydromorphology of tropical rivers, refining socio-cultural parameters to better address river services and widespread urban challenges, and balancing trade-offs between ecological and social restoration goals.
Austria is committed to the net-zero climate goal along with the European Union. This requires all sectors to be decarbonized. Hereby, hydrogen plays a vital role as stated in the national hydrogen strategy. A report commissioned by the Austrian government predicts a minimum hydrogen demand of 16 TWh per year in Austria in 2040. Besides hydrogen imports, domestic production can ensure supply. Hence, this study analyses the levelized cost of hydrogen for an off-grid production plant including a proton exchange membrane electrolyzer, wind power and solar photovoltaics in Austria. In the first step, the capacity factors of the renewable electricity sources are determined by conducting a geographic information system analysis. Secondly, the levelized cost of electricity for wind power and solarphotovoltaics plants in Austria is calculated. Thirdly, the most cost-efficient portfolio of wind power and solar photovoltaics plants is determined using electricity generation profiles with a 10-min granularity. The modelled system variants differ among location, capacity factors of the renewable electricity sources and the full load hours of the electrolyzer. Finally, selected variables are tested for their sensitivities. With the applied model, the hydrogen production cost for decentralized production plants can be calculated for any specific location. The levelized cost of hydrogen estimates range from 3.08 EUR/kg to 13.12 EUR/kg of hydrogen, whereas it was found that the costs are most sensitive to the capacity factors of the renewable electricity sources and the full load hours of the electrolyzer. The novelty of the paper stems from the model applied that calculates the levelized cost of renewable hydrogen in an off-grid hydrogen production system. The model finds a cost-efficient portfolio of directly coupled wind power and solar photovoltaics systems for 80 different variants in an Austria-specific context.
The use of nematic liquid crystal (LC) mixtures for microwave frequency applicationspresents a fundamental drawback: many of these mixtures have not been properly characterizedat these frequencies, and researchers do not have an a priori clear idea of which behavior they canexpect. This work is focused on developing a new procedure for the extraction of the main parametersof a nematic liquid crystal: dielectric permittivity and loss tangent at 11 GHz under differentpolarization voltages; splay elastic constantK11, which allows calculation of the threshold voltage(Vth); and rotational viscosityγ11, which allows calculating the response time of any arbitrary device.These properties will be calculated by using a resonator-based method, which is implementedwith a new topology of substrate integrated transmission line. The LC molecules should be rotated(polarized) by applying an electric field in order to extract the characteristic parameters; thus,the transmission line needs to have two conductors and low electric losses in order to preserve theintegrity of the measurements. This method was applied to a well-known liquid crystal mixture(GT3-23002 from MERCK) obtaining the permittivity and loss tangent versus bias voltage curves,the splay elastic constant, and the rotational viscosity of the mixture. The results validate the viabilityof the proposed method.