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This market research paper has been prepared under the supervision of Prof. Dr. Wolfgang Veit of TH Köln and Prof. Dr. Carol Scovotti of University of Wisconsin-Whitewater in the course of the inter-university cross-border collaboration student research project “Export Opportunity Surveys (EOS)”. This study explores organic lipstick export opportunities to the German and US markets.
Water shortage and a rising water demand are prevalent issues on the political agenda worldwide. Available water resources must not only be provided to ensure a domestic and drinking water supply for a steadily increasing population but also for the growing industrial and agricultural sectors. This work outlines how the use of the innovative vacuum multi‐effect membrane distillation contributes to improve the water management efficiency in the following key industry sectors: desalination, drinking water and beverage industry, pharmaceutical, agro and chemical as well as oil and gas industry.
Ecosystems provide a wide range of goods, services or ecosystem services (ES) to society. Estimating the impact of land use and land cover (LULC) changes on ES values (ESV) is an important tool to support decision making. This study used remote sensing and GIS tools to analyze LULC change and transitions from 2001 to 2016 and assess its impact on ESV in a tropical forested landscape in the southern plains of Nepal. The total ESV of the landscape for the year 2016 is estimated at USD 1264 million year−1. As forests are the dominant land cover class and have high ES value per hectare, they have the highest contribution in total ESV. However, as a result of LULC change (loss of forests, water bodies, and agricultural land), the total ESV of the landscape has declined by USD 11 million year−1. Major reductions come from the loss in values of climate regulation, water supply, provision of raw materials and food production. To halt the ongoing loss of ES and maintain the supply and balance of different ES in the landscape, it is important to properly monitor, manage and utilize ecosystems. We believe this study will inform policymakers, environmental managers, and the general public on the ongoing changes and contribute to developing effective land use policy in the region.
Metallic tubular micro-components play an important role in a broad range of products,
from industrial microsystem technology, such as medical engineering, electronics and optoelectronics, to sensor technology or microfluidics. The demand for such components is increasing, and forming processes can present a number of advantages for industrial manufacturing. These include, for example, a high productivity, enhanced shaping possibilities, applicability of a wide spectrum of materials and the possibility to produce parts with a high stiffness and strength. However, certain difficulties arise as a result of scaling down conventional tube forming processes to the microscale. These include not only the influence of the known size effects on material and friction behavior, but also constraints in the feasible miniaturization of forming tools. Extensive research work has been conducted over the past few years on micro-tube forming techniques, which deal with the development of novel and optimized processes, to counteract these restrictions. This paper reviews the relevant advances in micro-tube fabrication and shaping. A particular focus is enhancement in forming possibilities, accuracy and obtained component characteristics, presented in the reviewed research work. Furthermore, achievements in severe plastic deformation for micro-tube generation and in micro-tube testing methods are discussed.
Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the efficacious treatment of patients by reduction of therapy options and subsequent treatment failure. Various mechanisms are described to be involved in the development of MDR with overexpression of ATP-binding cassette (ABC) transporters reflecting the most extensively studied. These membrane transporters translocate a wide variety of substrates utilizing energy from ATP hydrolysis leading to decreased intracellular drug accumulation and impaired drug efficacy. One treatment strategy might be inhibition of transporter-mediated efflux by small molecules. Isocoumarins and 3,4-dihydroisocoumarins are a large group of natural products derived from various sources with great structural and functional variety, but have so far not been in the focus as potential MDR reversing agents. Thus, three natural products and nine novel 3,4-dihydroisocoumarins were designed and analyzed regarding cytotoxicity induction and inhibition of human ABC transporters P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) in a variety of human cancer cell lines as well as the yeast ABC transporter Pdr5 in Saccharomyces cerevisiae. Dual inhibitors of P-gp and BCRP and inhibitors of Pdr5 were identified, and distinct structure-activity relationships for transporter inhibition were revealed. The strongest inhibitor of P-gp and BCRP, which inhibited the transporters up to 80 to 90% compared to the respective positive controls, demonstrated the ability to reverse chemotherapy resistance in resistant cancer cell lines up to 5.6-fold. In the case of Pdr5, inhibitors were identified that prevented substrate transport and/or ATPase activity with IC50 values in the low micromolar range. However, cell toxicity was not observed. Molecular docking of the test compounds to P-gp revealed that differences in inhibition capacity were based on different binding affinities to the transporter. Thus, these small molecules provide novel lead structures for further optimization.
Durch das permanente Wachstum der Weltbevölkerung wird der Bedarf von Textilien stetig steigen. Die Produktvielfalt sowie der Konsum der Textilien werden immer größer. Die aktuellen Recyclingtechniken ermöglichen es nicht, den Rohstoffkreislauf für Textilien zu schließen. Dies liegt auch darin begründet, dass derzeit große Mengen der Textilien aus Mischgeweben zwischen Baumwolle und PET bestehen. Die Trennung dieser Komponenten ist jedoch eine Grundvoraussetzung für die Entwicklung eines geschlossenen Rohstoffkreislaufs und stellt gleichzeitig eine große Herausforderung für das Recycling dar. Durch chemische Recyclingverfahren können die Rohstoffe getrennt, aufbereitet und in die Textilproduktion zurückgeführt werden. In dieser Arbeit wird aufgezeigt, wie ein chemischer Recyclingprozess, der einen geschlossenen Rohstoffkreislauf erlaubt, technisch realisiert werden kann. Der Prozess erzeugt eine PET-Fraktion und eine Celluloselösung, die in weiteren Verarbeitungsschritten zu einer Regeneratfaser versponnen wird. In dieser frühen Projektphase werden in dieser Arbeit ebenfalls die Investitionsausgaben und die Herstellungskosten für das Verfahren abgeschätzt.
Die vorliegende Masterarbeit behandelt die Bewertung der eingegangenen Unternehmensrisiken im Rahmen der Lebensversicherung und die hiervon abgeleiteten Auswirkungen zur Unternehmenssteuerung.
Dabei wird einerseits die Angemessenheit der sog. „Standardformel“ nach Solvency II überprüft, die in den europäischen Mitgliedsstaaten einen weitestgehend einheitlichen Ansatz bei der Bewertung der Risiken von Versicherungsunternehmen verwendet. Andererseits werden unter ökonomischen Überlegungen versicherungsmathematische Methoden vorgestellt, wie ein Lebensversicherer seine Risiken unternehmensindividueller ermitteln und damit seinen tatsächlichen Risikokapitalbedarf bestimmen kann.
Zur Quantifizierung der Ergebnisse werden die Berechnungsvorgaben der Standardformel für ausgewählte Risikomodule nachgebildet und mit den in dieser Arbeit vorgestellten unternehmensindividuellen Berechnungen verglichen und analysiert. Es zeigt sich, dass trotz der Komplexität des Solvency II-Modells eine noch differenziertere Herangehensweise notwendig ist, damit ein einzelnes Unternehmen seine Risiken adäquat und möglichst individuell bestimmen kann. Zur Gewährleistung einer nicht bestandsgefährdenden Unternehmensfortführung müssen die Versicherungsunternehmen bei Betrachtung ihrer Risiken mithilfe des EU-weiten Aufsichtssystems Solvency II in der Lage sein, die korrekten Rückschlüsse zur Unternehmenssteuerung zu ziehen. Die in dieser Arbeit vorgestellten versicherungsmathematischen Ansätze können dabei den Prozess zur unternehmenseigenen Risiko- und Solvabilitätsbeurteilung (ORSA) unterstützen.
The climate is changing and this increases the risk of climate threats, which is affecting the most vulnerable populations, mainly peasant farmers. In order to minimize impacts on these populations, interest has been aroused to develop strategies that increase their resilience to climate-related risks. This issue has been little addressed in Ecuador, despite the increased frequency and intensity of climate-related risks, which are directly affecting agroecosystems and farmers' livelihoods. This research addresses the resilience of farmers to climate risks in the canton of Pedro Carbo, an area located on the Ecuadorian coast of Guayas Province characterized by a high rate of poverty and dedicated mainly to agriculture.
The overall objective of this research was to carry out an analysis of the resilience of small farmers to climate risks, as well as to recommend adaptation/transformation strategies to increase their resilience to climate. For this, farmers' perceptions were considered, as well as the opinion of experts on the subject. Multiple methods were applied such as: literature review, map generation, household surveys, participatory workshops with farmers and interviews with experts. In addition, a multidimensional matrix was developed to analyze quantitative and qualitative data through indicators that measure resilience in the study area. The main findings in this research reflect that farmers have very low resilience due to their socioeconomic characteristics, agricultural practices, lack of infrastructure and technologies, weak community organizations, limited access to credit and insurance, as well as lack of capacity building and technical assistance. Finally, recommendations for strategies to support planning and decision-making were developed.
Keywords: climate-related risks, peasant family farming, resilience, resilience assessment, climate resilience, farmers perceptions, Pedro Carbo
While global food production greatly exceeds dietary energy demand, undernutrition remains, and diets largely fail to ensure the health of the population. Agricultural biodiversity is crucial for the world’s food security, but genetic diversity has been degraded. In Mexico, the dietary transition towards processed foods has contributed to malnutrition and a rise of diet-related chronic diseases. Mexico’s indigenous people are conserving and creating valuable plant genetic resources in their swidden milpas and traditional agroforestry systems but remain the country’s most vulnerable population group. The Teenek (or Huastec), an indigenous group that habitat the Huasteca Potosina, a region in north-eastern Mexico cultivate a high diversity of edible plants in their home gardens (solar), milpas, and agroforestry systems (te’lom, or finca). However, migration has been leading to the abandonment of traditional farming in the region.
The objective of this study was to analyse if the managed agricultural biodiversity of the different traditional land use systems contributes to the food security of the farming households in the community of Jol Mom. Food availability and access were investigated. In total, 40 households were surveyed. Dietary patterns were identified through principal component analysis. Informal interviews, semi-structured interviews and participant observation allowed to account for the people’s own perceptions and provided additional insights. Findings showed that traditional Teenek farming systems are the source of a variety of nutritious foods and resulted to be the most important provider of fruits and vegetables. The average production diversity was 34 out of 56 crops, farmers cultivating more than one or two farming systems showed an increase of four and 11 produced species respectively. Production diversity was strongly correlated with food variety in a household’s diet, with an increment of one per 0.85 produced crop. Two main diverging dietary patterns were revealed, a westernized diet relying largely on purchased foods, to which the younger generation was more inclined, and a traditional diet characterized by a high consumption of cultivated products, mostly observed in the older households.
In conclusion, farming households in Jol Mom profit from the agricultural diversity of their production systems, either through the consumption of nutritious foods or by the sale of agricultural products. However, a tendency towards nutrient-poor diets was observed. Increasing agricultural diversity and consumption of locally produced foods might help to fight this trend but would require a valorisation of traditional foods and an appreciation of the contribution of indigenous people’s traditional agriculture to food security.
In dieser Arbeit wird die Frage nach der Zusammensetzung einer aus konservatorischer Sicht unbedenklichen Stempelfarbe untersucht. Es konnten vier Kategorien von Stempelfarben ermittelt werden: die leinölhaltigen, die mineralölhaltigen, die glykol-/glycerolhaltigen und die harzhaltigen. Neun Stempelfarben aus diesen vier Kategorien wurden in einer umfangreichen Testreihe auf ihre Licht- und Klimabeständigkeit, ihre Löse- und Bleichmittelfestigkeit, ihre Wischfestigkeit und ihr Durchschlagvermögen überprüft. Drei rein pigmenthaltige Stempelfarben haben diese Tests bestanden. Von diesen hatte nur die leinölhaltige Stempelfarbe eine gute Dokumentenechtheit. Zudem werden im letzten Kapitel Möglichkeiten zur Entfernung von Stempelfarben auf Papier vorgestellt.