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Thioredoxin (Trx) overexpression is known to be a cause of chemotherapy resistance in various tumor entities. However, Trx effects on resistance are complex and depend strictly on tissue type. In the present study, we analyzed the impact of the Trx system on intrinsic chemoresistance of human glioblastoma multiforme (GBM) cells to cytostatic drugs. Resistance of GBM cell lines and primary cells to drugs and signaling inhibitors was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Impact of Trx inhibition on apoptosis was investigated by proteome profiling of a subset of proteins and annexin V apoptosis assays. Trx-interacting protein (TXNIP) was overexpressed by transfection and protein expression was determined by immunoblotting. Pharmacological inhibition of Trx by 1-methyl-2-imidazolyl-disulfide (PX-12) reduced viability of three GBM cell lines, induced expression of active caspase-3, and reduced phosphorylation of AKT-kinase and expression of β-catenin. Sensitivity to cisplatin could be restored by both PX-12 and recombinant expression of the upstream Trx inhibitor TXNIP, respectively.
In addition, PX-12 also sensitized primary human GBM cells to temozolomide. Combined inhibition of Trx and the phosphatidylinositide 3-kinase (PI3K) pathway resulted in massive cell death. We conclude that the Trx system and the PI3K pathway act as a sequential cascade and could potentially present a new drug target.
The 11th Annual Meeting of the Sponsoring Group Reinsurance (Förderkreis
Rückversicherung) on the topic of reinsurance was held 13 July 2018, in
Niederkassel near Cologne. Some 85 invited representatives of the (re)insurance
companies supporting the Sponsoring Group took part in the meeting, together with
guests. Offered for the fourth time as part of the Annual Meeting, the Researchers’
Corner gave eight members of academic staff at the Cologne Research Centre for
Reinsurance an opportunity to deliver a presentation on their respective individual
research projects.
Professor Materne also conducted interviews with Dr. Falk Niehörster (Climate Risk
Innovations) and Dr. Magnus Kobel (YAS.life). Dr. Niehörster reported on his
research and consulting activities in regard to maritime climate change and Dr. Kobel
on the business model of his InsurTec, YAS.life, and his general experience in the
establishment and development of start-ups.
In three sessions – each with 2-3 parallel lectures with posters – the most important
results of the scientific studies by the Cologne Research Centre for Reinsurance were
presented and discussed. The heterogeneity of the topics presented by academic
staff reflects the dovetailing of research theory with practice.
The reinsurance market is currently faced with great challenges and profound changes. Even after the large NatCat claims in Q3-2017, the substantial hardening of the reinsurance market for which reinsurers had hoped failed to materialise in the year-end renewal. Interest is now focussed on the renewal of retrocession agreements as at 1st April 2018. The Cologne Research Centre for Reinsurance analyses the latest developments in the reinsurance market and, where appropriate, monitors these through research projects.
In the process, the Cologne Research Centre for Reinsurance links its research activities with practices in the reinsurance sector. Hereby, and facilitated through organisation of the annual Cologne Reinsurance Symposium and the Annual Meeting of the Sponsoring Group Reinsurance, a bi-directional transfer of knowledge between theory and practice is pursued. The content of these two scientific events, as well as the completed research projects, are incorporated into scholarship and instruction at the Institute of Insurance Studies, rounding out practice-oriented training in the field of reinsurance. Currently, there are seven researchers and two coordinating employees on the staff of the Cologne Research Centre for Reinsurance. Thereby, all material and personnel costs are fully financed by third-party funds provided by the Sponsoring Group Reinsurance. We want to thank the Sponsoring Group Reinsurance, the University leadership and administration, and the employees of the Cologne Research Centre for Reinsurance for all their support for the research projects and events of the past year.
The 10th Annual Meeting of the Sponsoring Group Reinsurance was held 7 July 2017, in Niederkassel
near Köln. Some 80 representatives of the (re)insurance companies involved in the Sponsoring Group took part in the meeting, together with invited guests. Offered for the third time as part of the Annual Meeting, the Researchers’ Corner gave nine members of academic staff at the Cologne Research Centre for Reinsurance an opportunity to deliver short presentations on their individual research projects. Professor Materne also conducted interviews with Messrs Lorenz Kielwein and
Frank Baumann. Kielwein reported on the application of mathematical systems theory to processes in change management, and Baumann on his 30 years of experience at Gothaer. During each of three sessions, three short lectures with posters were held in parallel and discussed afterwards. The heterogeneity of the topics presented by the staff members reflects the dovetailing
of research theory with practice.
In the sessions, the following speakers presented in German and English:
Round 1
a) Fabian Pütz (M.Sc.)
Alternative Capital and Basic Risk in the Standard Formula (Non-Life) of Solvency II
b) Manuel Dietmann (M.Sc.)
SFCR: Findings for Initial Publication
c) Jan Böggemann (B.Sc.)
Optimising the Purchase of Optional Reinsurance by an Industrial Insurer
Round 2
a) Robert Joniec (M.Sc.)
Actuarial swap
b) Lucas Kaiser (M.Sc.)
The Impact of Different Determinants on the Rating of Reinsurance Companies
c) Lihong Wang (M.Sc., FCII)
Chinese Automobile Vehicle Recall Insurance
Round 3
a) Sebastian Hoos (M.Sc., FCII)
Critical Analysis of the Practical Application of the Definition of an Event
b) Fabian Lassen (B.A.)
Employees in the Reinsurance Industry: Germany and the USA.
c) Kai-Olaf Knocks (M.A., FCII)
[Autonomous Driving: Evolution or Revolution?
The presentations also featured the work of another member of our staff who unfortunately, for
logistical reasons, was able to present his research project in poster form but was not able to deliver
a brief lecture.
Poster
d) Wolfgang Koch (B.A.)
Public-Private Partnership in Emerging and Developing Countries.
We would like to thank the funding bodies who make this event possible to begin with and provide our scholars an opportunity to conduct their research.
Worldwide there is a big need for affordable livingspace. Globalization leads to a connection of development and ideas in the field of building. Open Source communities could improve and accelerate this development. The potential of theses communities lies in the connection of different diciplines. Especially for building projects with a small budget and a willingness to participate in the work process open source do-it-yourself constructions are a great opportunity to help cover the need of affordable work and living space. Renewable materials such as wood offer great potential here. New, standardised technologies make a decentralised production possible.
Policy measures are essential tools for the transition from fossil fuels to renewable energy sources in the electricity generation. Feed-in tariffs (FITs) are the most used policy for support of renewable technologies globally. Nevertheless, Ecuador phased-out FITs in 2016 and adopted auctions in 2015. Ecuador’s implementation of auctions reflects an approach with little relation to practices in other countries and without a technology-specific design. On the other hand, Germany demonstrates a long trajectory in policy-making with vast experience in FITs. Moreover, in 2017 Germany adopted auctions as the official policy to support renewable projects with a scope larger than 750 kW. However, FITs are still in use and complement auctions.
This thesis analyses and compares the country-specific contexts where these policies are implemented through the lens of a multi-level perspective framework. As a result, the most important success factors in Germany have been identified: long-term planning, institutional continuity, legislative stability and principally an actively participating society, which is environmentally aware. Obstacles for the transition in Ecuador are institutional discontinuity, legislative inconsistency, the lack of long-term planning and absence of society as actors of the transition. Due to Germany’s pioneering role plus the successful growth of renewable sources during the last twenty years, their policy implementations appear desirable to adopt in other contexts. Therefore, a prospective transferability of the auction policy from Germany to Ecuador is additionally analyzed.
Observational studies and clinical trials have become increasingly important over recent years and play an essential role in advancing medical knowledge. In today’s world of clinical research, it is not possible to imagine trials without the founda-tion of a well-established it-infrastructure. Electronic capture and usage of data is pervasive.
In practice, medical progress requires the ability to integrate data from different systems. An essential factor in enabling different actors, such as institutions and hospitals, to have their systems exchange structured data and make use of the information is the interoperability of the data and systems.
FHIR (Fast Healthcare Interoperable Resources) is a free and easily customizable HL7 platform standard, based on 30 years of experience of HL7. It is focused on providing health-related information and defines a set of capabilities used in the health care process.
This thesis will provide a conceptual approach for working with FHIR, as well as concrete approaches for working with FHIR profiles and for customizing the standard for particular use cases. It will be carried out in cooperation with the Medical Systems R&D, which is a service provider within the University Hospital of Cologne.
The guiding request approach will focus on the evaluation of requirements for clini-cal trials and how clinical research protocols can be represented in an interoperable and machine-parsable format using FHIR.
Illegal Gold mining and water quality. A case study of River Offin in the Central Region of Ghana
(2018)
Ghana as a country in the west of Africa is naturally endowed with many rich natural resources some of which includes; Gold, diamond, bauxite, manganese, cocoa, etc. Currently, it’s the second leading producer of gold production in Africa after South Africa. Gold production has produced a lot of benefits to the nation but at the same time contributed to many negativities ranging from pollution (water and air), land degradation, ethnic conflicts and deforestation. Industrial gold mining itself was never a big issue that caused any panic in the country till illegal gold miners “Galamseyers” also commenced operating. The sole objectives of this research were to determine the level of some specific heavy metal (Mercury, Lead, Arsenic and Zinc) concentrations within the Offin River in Dunkwa-on-Offin, Buabenso, Ayanfuri and Nkotumso. Results after the research revealed that, Ayanfuri recorded the highest level of concentrations. Nkotumso followed in that order before Buabenso with Dunkwa-on-Offin recording the least concentrations. It also became clear later that, even though the degree of intensiveness of the illegal mining “Galamsey” operations could have been a main factor for the increased concentrations, another finding was that, towns or communities that recorded higher concentrations throughout the study also showed to be towns that made use of inorganic fertilizers on its farms. The Minerals and mining Act 2006 of Ghana was then analyzed and conclusion was that, though the country has very strong policies regarding illegal mining termed “Galamsey”, there seemed to be institutional loop holes that have not been strong enough to combat illegal mining in the country. In recommending policy directives to improve the river quality, six (6) institutions including the Ministry of Lands and Natural Resources, Ministry of Environment, Science and Technology(MEST), Minerals Commission of Ghana, Environmental Protection Agency, Forestry Commission and the water Resources Commission were identified with detailed recommended roles clearly spelt out for each institution.
Blogging has established itself as an important and influential part of the
modern online media. At the dawn of the blogosphere people were publishing
their diaries and life journals. Nowadays, some bloggers operate blogs that are
hardly any different from online newspapers and magazines. On the one hand
professional blogging is broadly accepted in the society, but on the other hand
it is poorly understood. The purpose of this explorative study is to broaden
the understanding of blogging as a professional activity. In particular, this
study explores the aspects of professional blogging and the interplay between
credibility, authenticity and monetisation in blogs.
To understand blogging as a professional activity an extensive literature
research is conducted. First, main concepts of blogging as a social activity
are discussed. Then, the changes that come together with the transformation
of a social activity into a professional activity of blogging are discussed. To
look at the activity of blogging from an unusual perspective, a comprehensive
qualitative survey is conducted with blog readers. The survey examines
not only readers’ perception of blogging as a professional activity, but also
motivations for reading blogs and attitude to monetising practices and labelling
of monetised content in blogs. Information received from the survey is used to
draw some conclusions about the state of the art of blogging as a professional
activity, and challenges and opportunities blogging industry faces nowadays.
The Highland Plateau region, in San Luis Potosí, involves particular dynamics and needs from those presented within the rest of the state; its culture, vocation, mineral resources and territory, converge to give rise to a unique and particular region. The connectivity within the region has been decisive for its development, since two of the largest and most important national roads in go through this territory.
Despite comprehending about a half of the state's territory, this region has not managed to truly influence the state statistics neither economically nor socially; on the contrary, the employment rate has significantly decreased significantly, and also its population number.
Accordingly, this research aims to analyze the connectivity system within this region to strengthen and complement the development tools of these communities in a sustainable manner and, in this way, increase the welfare of the Highland Plateau population.
Throughout this investigation, it will be possible to understand how the location of this physical network, as well as for the use of resources for the satisfaction of the inhabitants, has been reflected in the communities within this region. Likewise, the statements made by state directors in charge of the economy, road network and social development within the region, will be studied. These statements will also be combined with a “functional grid analysis”, the connectivity between communities and their basic needs.