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Due to the global phenomenon of climate change the region of Mara Siana is projected to increasingly face extreme weather events that particularly comprise prolonged droughts and
heavier rainfalls. To be able to adequately adapt to these changing circumstances and maintain their livelihoods communities need to build respective capacities. As the main objective, this research aims at determining landowners’ climate change adaptative capacity (CCAC) across different villages in Mara Siana. Accordingly, a semi-quantitative approach was carried out including qualitative interviews and the subsequent quantitative calculation of CCAC based on a multidimensional indicator set and a respective coding
system. In addition to predominantly positive results of socio-cultural characteristics and the quality of natural resources, this work reveals clear weaknesses and potential for improvement in the areas of income security and financial stability, the expansion and resilience of infrastructure, and the relationship between communities and local authorities. Moreover, differences in capacity results are not only identified between the investigated villages as well as between individual households but also systemic disadvantage in capacity building affecting female landowners and community members can be indicated from the obtained interview data. Therefore, this research gives concrete recommendations for the implementation and verification of suitable adaptive measures that are particularly tailored for the improvement of low-performance indicators while following a gendertransformative approach and thus hold the potential to increase CCAC in the long-term.
Elaeis guineensis Jacq. or oil palm is a native species of West Africa. Its oils, extracted from the fruit mesocarp and the kernel are widely used in the food industry, industrial applications, and bioenergy production. Due to its versatility, profitability and growing demand, the global oil palm agroindustry raises concerns regarding deforestation, effects in biodiversity, contamination and related to social issues such as labor conditions, poverty, and social conflicts. In Mexico, the establishment and subsequent growth of the oil palm industry was promoted by past government policies and financial support. In Chiapas the current main producer of the country, the expansion can be also attributed to oil palm resilience to floods, hurricanes, and the economic profitability.
The objective of this study is to evaluate the sustainability status of the oil palm production system within Acapetahua and Villa Comaltitlán Municipalities by analyzing the indicators of sustainability. To achieve this, the Evaluation Framework for Natural Resource Management Systems (MESMIS), was adapted to measure the attributes status of productivity, stability, reliability, resilience, self-management, equity, and adaptability, of the different dimensions of sustainability (environmental, social, political, and economic).
It was identified that MESMIS is an appropriate framework to study oil palm system in Acapetahua and Villa Comaltitlán municipalities. The methodology allowed the identification of critical points, and relevant indicators that include land use and vegetation cover changes, oil palm cashflow, good agricultural practices, farmers´ training, level of participation and farmers´ well-being. As a result, it was identified that vegetation and land use changes were principally from pastures land and previous oil palm plantations, and a positive profitability in the last two years. Soil and water conservation practices are implemented, and farmers have received different trainings principally from social mills, but other good agricultural practices and awareness of social problems should be improved, while the social participation evaluation showed a weak status of the political dimension.
Acknowledging the ways in which design (as practices, forms of knowledge, and sets of objects) is accountable for ongoing social and environmental injustices, this anthology contains contributions that envision alternative ways of exploring and designing more livable futures. Attending to these futures requires a reckoning with a multiplicity of actors and contexts, from institutional norms and regulations, to pedagogies, curricula, programs, digital tools, infrastructures, and architectural environments. Last but not least, attention is drawn to the mechanisms and protocols by which these futures are imagined and shaped. This includes critically examining the ways in which design is talked about, taught, and learned in order to empower future designers to engage with the political issues, cultural conditions, and social and environmental implications of their work.
The 16th Annual Meeting of the Sponsoring Group Reinsurance [Förderkreis Rückversicherung] was held 16 June 2023 in Niederkassel, near Cologne. Some 90 representatives of the (re)insurance companies involved in the Sponsoring Group
took part in the meeting, along with guests. Offered for the ninth time as part of the Annual Meeting, the Researchers’ Corner gave the six academic researchers at the Cologne Research Centre for Reinsurance an opportunity to deliver a presentation on the research project in which each is involved in 2023. Over the course of three sessions, the most important results of the scientific studies by the Cologne Research Centre for Reinsurance were presented and discussed.
The heterogeneity of the topics presented reflects the dovetailing of Cologne Research Centre with reinsurance practice.
Catastrophe insurance without premium payment – The concept of contigent liability in Switzerland
(2023)
No later than with the heavy rainfalls of 2021, discussions in Germany have resumed around the introduction of compulsory insurance for natural hazards. Natural hazards exhibit a high potential for loss, and insurance is a building block with which to bolster resilience. In practice, there are already a host of functioning solution concepts to provide cover for natural hazards, including insurance pools and state guarantees. All of the concepts, however, are predicated on payment of an ongoing insurance premium.
In its Renewables 2022 Report, the International Energy Agency (IEA) projects that the share of renewable energies in the global energy mix will increase from 22.8% in 2015 to 38.1% in 2027. This trend goes hand-in-hand with increasing construction of plants for the generation of renewable energies, leading to increased demand for (re)insurance. Comparable to the development of traditional energy sources, the hedging of current risks is a key element in the further development of renewable energies. According to projections by the IEA, by 2027 most of the energy from renewable sources will be generated using photovoltaics or solar as well as onshore and offshore wind.
The prolonged US-China trade tension, initiated in 2017, has led to significant consequences, impacting global supply chains and causing economic tension between the two largest economies. Particularly affecting the automotive sector, the trade war has influenced motor insurance premiums in China, contributing to a declining trend in non-life insurance growth rates from 2017 to 2021. However, a positive outlook is projected for 2023-2026, indicating potential recovery opportunities. The trade war's short-term impacts on the Chinese motor insurance market include increased costs, low premium growth, and economic challenges. In the long term, transformative changes, including market diversification, innovative products, data-driven pricing, and technology-enabled risk prevention, are expected to shape a dynamic and competitive motor insurance landscape in China, offering growth potential despite initial challenges.
In this work, we propose a novel data-driven approach to recover missing or corrupted motion capture data, either in the form of 3D skeleton joints or 3D marker trajectories. We construct a knowledge-base that contains prior existing knowledge, which helps us to make it possible to infer missing or corrupted information of the motion capture data. We then build a kd-tree in parallel fashion on the GPU for fast search and retrieval of this already available knowledge in the form of nearest neighbors from the knowledge-base efficiently. We exploit the concept of histograms to organize the data and use an off-the-shelf radix sort algorithm to sort the keys within a single processor of GPU. We query the motion missing joints or markers, and as a result, we fetch a fixed number of nearest neighbors for the given input query motion. We employ an objective function with multiple error terms that substantially recover 3D joints or marker trajectories in parallel on the GPU. We perform comprehensive experiments to evaluate our approach quantitatively and qualitatively on publicly available motion capture datasets, namely CMU and HDM05. From the results, it is observed that the recovery of boxing, jumptwist, run, martial arts, salsa, and acrobatic motion sequences works best, while the recovery of motion sequences of kicking and jumping results in slightly larger errors. However, on average, our approach executes outstanding results. Generally, our approach outperforms all the competing state-of-the-art methods in the most test cases with different action sequences and executes reliable results with minimal errors and without any user interaction.
Austria is committed to the net-zero climate goal along with the European Union. This requires all sectors to be decarbonized. Hereby, hydrogen plays a vital role as stated in the national hydrogen strategy. A report commissioned by the Austrian government predicts a minimum hydrogen demand of 16 TWh per year in Austria in 2040. Besides hydrogen imports, domestic production can ensure supply. Hence, this study analyses the levelized cost of hydrogen for an off-grid production plant including a proton exchange membrane electrolyzer, wind power and solar photovoltaics in Austria. In the first step, the capacity factors of the renewable electricity sources are determined by conducting a geographic information system analysis. Secondly, the levelized cost of electricity for wind power and solarphotovoltaics plants in Austria is calculated. Thirdly, the most cost-efficient portfolio of wind power and solar photovoltaics plants is determined using electricity generation profiles with a 10-min granularity. The modelled system variants differ among location, capacity factors of the renewable electricity sources and the full load hours of the electrolyzer. Finally, selected variables are tested for their sensitivities. With the applied model, the hydrogen production cost for decentralized production plants can be calculated for any specific location. The levelized cost of hydrogen estimates range from 3.08 EUR/kg to 13.12 EUR/kg of hydrogen, whereas it was found that the costs are most sensitive to the capacity factors of the renewable electricity sources and the full load hours of the electrolyzer. The novelty of the paper stems from the model applied that calculates the levelized cost of renewable hydrogen in an off-grid hydrogen production system. The model finds a cost-efficient portfolio of directly coupled wind power and solar photovoltaics systems for 80 different variants in an Austria-specific context.
Abstract
Even though researchers are increasingly acknowledging the dark side of customer participation (i.e., behavioral customer engagement), particularly in professional services with high cognitive demands that cause customer participation stress (i.e., negative psychological state resulting from the customer's overextension by required customer participation efforts), insights on how firms can effectively mitigate customer participation stress remains limited. Building on transactional stress theory, we investigate whether customers can effectively cope with the expected cognitive demands of professional services. Moreover, by introducing an adapted coping construct (i.e., coping support), we examine whether employees can provide coping support to help decrease customer participation stress. The findings of a time‐lagged field study with customers of a large German bank (N = 117) suggest that customer coping before the encounter cannot mitigate the effect of anticipated cognitive demands on customer participation stress. Instead, the results of both the field study and a follow‐up experimental study (N = 218) show that a certain set of employee coping support during service encounters is crucial. While focusing on action coping support is not ideal in situations with high cognitive demands, firms should advise their professional service employees to offer emotional coping support to attenuate the unfavorable effect of cognitive demands on customer participation stress.
As the population ages, the demand for care for older adults is increasing. To maintain their independence and autonomy, even with declining health, assistive technologies such as connected medical devices or social robots can be useful. In previous work, we introduced a novel health monitoring system that combines commercially available products with apps designed specifically for older adults. The system is intended for the long-term collection of subjective and objective health data. In this work, we present an exploratory user experience (UX) and usability study we conducted with older adults as the target group of the system and with younger expert users who tested our msystem. All participants interacted with a social robot conducting a health assessment and tested sensing devices and an app for data visualization. The UX and usability of the individual components of the system were rated highly in questionnaires in all sessions. All participants also said they would use such a system in their everyday lives, demonstrating the potential of these systems for self-managing users’ health. Finally, we found factors such as previous experience with social robots and technological expertise to have an influence on the reported UX of the users.
To date, the establishment of high-titer stable viral packaging cells (VPCs) at large scale for gene therapeutic applications is very time- and cost-intensive. Here we report the establishment of three human suspension 293-F-derived ecotropic MLV-based VPCs. The classic stable transfection of an EGFP-expressing transfer vector resulted in a polyclonal VPC pool that facilitated cultivation in shake flasks of 100 mL volumes and yielded high functional titers of more than 1 × 106 transducing units/mL (TU/mL). When the transfer vector was flanked by transposon terminal inverted repeats (TIRs) and upon co-transfection of a plasmid encoding for the transposase, productivities could be slightly elevated to more than 3 × 106 TU/mL. In contrast and using mRNA encoding for the transposase, as a proof of concept, productivities were drastically improved by more than ten-fold exceeding 5 × 107 TU/mL. In addition, these VPC pools were generated within only 3 weeks. The production volume was successfully scaled up to 500 mL employing a stirred-tank bioreactor (STR). We anticipate that the stable transposition of transfer vectors employing transposase transcripts will be of utility for the future establishment of high-yield VPCs producing pseudotype vector particles with a broader host tropism on a large scale.
In recent years there have been numerous technical innovations such as CGM systems or insulin pumps that have made life easier for people with type 1 diabetes. However, this also means that more and more information is available. The aim of the present study is to find out more about the daily handling of information. The following research question was asked: What information do people with type 1 diabetes use? To answer this research question, a quantitative online survey of people with type 1 diabetes was conducted by Prof. Dr. Matthias Fank at the Technical University of Cologne. The online survey mainly consisted of 25 closed questions, which were asked on a scale from 0 to 10. The responses of 1,025 people who are at least 18 years old were included in the evaluation. The most important information for type 1 diabetics is the "current value". 67.5% have this on Place 1 placed. Current glucose levels are provided by CGM systems used by 94.2% of people with type 1 diabetes. Quarterly visits to the diabetologist are important and provide important information. 30.8% “completely” agree with this statement on a scale from 0 to 10. Only 2.2% of people with type 1 diabetes are satisfied with their current diabetes management apps. There is a desire for a manufacturer-independent app. The strongest agreement with a value of 10 was chosen by almost a quarter (24.6%) of the people with type 1 diabetes. The study provides an insight into diabetes therapy and shows the need for action.
Das Labor für Konstruktionstechnik der Technischen Hochschule Köln beschäftigt sich mit der Mikrodosierung von präzisen Strukturen von Silberleitklebstoff. Hauptsächlich wird bei derartigen Ventilen in berührende und berührungslose Dosierventile unterschieden. Zur Erzeugung dreidimensionaler elektrisch leitfähiger Strukturen können diese Dosierventile an entsprechende Verfahreinheiten adaptiert werden.
Porous polymer membranes substantially contribute to an acceleration of sustainability transformation based on the energy efficient separation of liquid and gaseous mixtures. This rapid shift toward sustainable industrial processes leads to an increased demand for specifically tailored membranes. In order to predict membrane performance factors like permeability, selectivity and durability, the membrane formation process by film casting and phase inversion needs to be understood further. In recent years, computational models of the membrane formation process have been studied intensely. Their high spatial and temporal resolution allows a detailed quantitative description of phase inversion phenomena. New experimental techniques complement this development, as they provide quantitative data, e.g., on compositional changes of the polymer solution during membrane formation as well as the kinetic progression of the phase separation process. This state-of-the-art review compiles computational and experimental approaches that characterize the phase inversion process. We discuss how this methodological pluralism is necessary for improving the tailoring of membrane parameters, but that it is unlikely to be the way to the ultimate goal of a complete description of the evolution of the membrane structure from the initial demixing to the final solidification. Alternatively, we formulate an approach that includes a database of standardized and harmonized membrane performance data based on previously publicized data, as well as the application of artificial neural networks as a new powerful tool to link membrane production parameters to membrane performance.
The Production of Isophorone
(2023)
Isophorone is a technically important compound used as a high-boiling-point solvent for coatings, adhesives, etc., and it is used as a starting material for various valuable compounds, including isophorone diisocyanate, a precursor for polyurethanes. For over 80 years, isophorone has been synthesized via base-catalyzed self-condensation of acetone. This reaction has a complex reaction mechanism with numerous possible reaction steps including the formation of isophorone, triacetone dialcohol, and ketonic resins. This review provides an overview of the different production processes of isophorone in liquid- and vapor-phase and reviews the literature-reported selectivity toward isophorone achieved using different reaction parameters and catalysts.
Agents with antifungal activity play a vital role as therapeutics in health care, as do fungicides in agriculture. Effectiveness, toxicological profile, and eco-friendliness are among the properties used to select suitable substances. Furthermore, a steady supply of new agents with different modes of action is required to counter the well-known potential of human and phyto-pathogenic fungi to develop resistance against established antifungals. Here, we use an in vitro growth assay to investigate the activity of the calcineurin inhibitor tacrolimus in combination with the commercial fungicides cyproconazole and hymexazol, as well as with two earlier reported novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines, against the fungi Aspergillus niger, Colletotrichum higginsianum, Fusarium oxysporum and the oomycete Phytophthora infestans, which are notoriously harmful in agriculture. When tacrolimus was added in a concentration range from 0.25 to 25 mg/L to the tested antifungals (at a fixed concentration of 25 or 50 mg/L), the inhibitory activities were distinctly enhanced. Molecular docking calculations revealed triazole derivative 5, (2-(3-adamantan-1-yl)-1H-1,2,4-triazol-5-yl)-4-chloroaniline), as a potent inhibitor of chitin deacetylases (CDA) of Aspergillus nidulans and A. niger (AnCDA and AngCDA, respectively), which was stronger than the previously reported polyoxorin D, J075-4187, and chitotriose. The results are discussed in the context of potential synergism and molecular mode of action.
During spaceflight, humans experience a variety of physiological changes due to deviations from familiar earth conditions. Specifically, the lack of gravity is responsible for many effects observed in returning astronauts. These impairments can include structural as well as functional changes of the brain and a decline in cognitive performance. However, the underlying physiological mechanisms remain elusive. Alterations in neuronal activity play a central role in mental disorders and altered neuronal transmission may also lead to diminished human performance in space. Thus, understanding the influence of altered gravity at the cellular and network level is of high importance. Previous electrophysiological experiments using patch clamp techniques and calcium indicators have shown that neuronal activity is influenced by altered gravity. By using multi-electrode array (MEA) technology, we advanced the electrophysiological investigation covering single-cell to network level responses during exposure to decreased (micro-) or increased (hyper-) gravity conditions. We continuously recorded in real-time the spontaneous activity of human induced pluripotent stem cell (hiPSC)-derived neural networks in vitro. The MEA device was integrated into a custom-built environmental chamber to expose the system with neuronal cultures to up to 6 g of hypergravity on the Short-Arm Human Centrifuge at the DLR Cologne, Germany. The flexibility of the experimental hardware set-up facilitated additional MEA electrophysiology experiments under 4.7 s of high-quality microgravity (10–6 to 10–5 g) in the Bremen drop tower, Germany. Hypergravity led to significant changes in activity. During the microgravity phase, the mean action potential frequency across the neural networks was significantly enhanced, whereas different subgroups of neurons showed distinct behaviors, such as increased or decreased firing activity. Our data clearly demonstrate that gravity as an environmental stimulus triggers changes in neuronal activity. Neuronal networks especially reacted to acute changes in mechanical loading (hypergravity) or de-loading (microgravity). The current study clearly shows the gravity-dependent response of neuronal networks endorsing the importance of further investigations of neuronal activity and its adaptive responses to micro- and hypergravity. Our approach provided the basis for the identification of responsible mechanisms and the development of countermeasures with potential implications on manned space missions.