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El presente artículo trata aspectos teóricos y prácticos de la traducción poética, concretamente de la traducción de poemas rimados, entre otras cosas con el objetivo de rebatir algunos clichés que se han ido afincando en España en la mentalidad de no pocos críticos y también de algunos traductores.
Das Ziel des vorliegenden Aufsatzes ist es, einen wichtigen Irrtum, der bei der Übersetzung einer der Maximen des Llibre d’amic e amat in die modernen Kultursprachen immer wieder auftaucht, aufzuzeigen und dessen Ursachen zu untersuchen. Es wurden Übersetzungen ins Deutsche, Englische, Französische, Spanische, Portugiesische und Italienische herangezogen. Zudem sollen grundsätzliche Unzulänglichkeiten bei der Übersetzung der Leidensmetaphorik in mystischen Texten besprochen werden.
Mojave. Així es titula el darrer recull d’August Bover. És un llibre que conté en total tres poemes, escrits en català i traduïts a l’anglès i al francès: una plaquette de 17 pàgines que es despleguen i formen tríptics trilingües. Tal com indica el nom del recull, tots tres poemes estan dedicats al gran desert californià i als pobles nadius nord-americans.
La presente comunicación se sitúa dentro del campo de la metodología fraseográfica bilingüe español-alemán y tiene por objeto tratar algunos aspectos relacionados con el definiens: se analizarán a) posibles alternativas; b) la conveniencia de recurrir, en algunos casos, a paráfrasis explicativas en la lengua terminal y las dificultades que ello implica; y c) el trato que deben recibir los equivalentes fraseológicos parciales, contextuales y unidireccionales. También se abordará la cuestión de cómo hay que citar ciertas unidades fraseológicas verbales del alemán en caso de que constituyan equivalentes a unidades del español y de cómo este hecho influye en la microestructura del diccionario.
Katalanische Lyrik heute
(2008)
En este artículo se estudia la función pragmática de las unidades fraseológicas idiomáticas del español de España en lo que a la comunicación de emociones se refiere. Nuestro análisis nos conduce a la conclusión de que un buen número de unidades fraseológicas expresan intensidad emotiva, e incluso nos atrevemos a afirmar que ello constituye una característica esencial al menos del sistema fraseológico del español. Esto es, las locuciones no tienen la función de indicar que alguien está contento, triste o enfadado, sino que suelen indicar que alguien está muy contento, muy triste o muy enfadado. En general, pensamos que las unidades fraseológicas son elementos idóneos para la transmisión de estados emotivos, dada su vaguedad característica, resultado del proceso de desemantización, lo cual concuerda con el carácter difuso de las emociones, y dados sus niveles de significado y su estructura interna.
El libro que comentamos representa una selección temática de los trabajos expuestos en el Congreso Internacional de Fraseología y Paremiología, celebrado en Santiago de Compostela del 18 al 22 de septiembre de 2006, e incluye trabajos en parte muy dispares y en parte coincidentes en cuanto al tema y al enfoque, cuyo común denominador es el análisis de las unidades fraseológicas desde el punto de vista de la lingüística de texto.
Thioredoxin (Trx) overexpression is known to be a cause of chemotherapy resistance in various tumor entities. However, Trx effects on resistance are complex and depend strictly on tissue type. In the present study, we analyzed the impact of the Trx system on intrinsic chemoresistance of human glioblastoma multiforme (GBM) cells to cytostatic drugs. Resistance of GBM cell lines and primary cells to drugs and signaling inhibitors was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Impact of Trx inhibition on apoptosis was investigated by proteome profiling of a subset of proteins and annexin V apoptosis assays. Trx-interacting protein (TXNIP) was overexpressed by transfection and protein expression was determined by immunoblotting. Pharmacological inhibition of Trx by 1-methyl-2-imidazolyl-disulfide (PX-12) reduced viability of three GBM cell lines, induced expression of active caspase-3, and reduced phosphorylation of AKT-kinase and expression of β-catenin. Sensitivity to cisplatin could be restored by both PX-12 and recombinant expression of the upstream Trx inhibitor TXNIP, respectively.
In addition, PX-12 also sensitized primary human GBM cells to temozolomide. Combined inhibition of Trx and the phosphatidylinositide 3-kinase (PI3K) pathway resulted in massive cell death. We conclude that the Trx system and the PI3K pathway act as a sequential cascade and could potentially present a new drug target.
Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the efficacious treatment of patients by reduction of therapy options and subsequent treatment failure. Various mechanisms are described to be involved in the development of MDR with overexpression of ATP-binding cassette (ABC) transporters reflecting the most extensively studied. These membrane transporters translocate a wide variety of substrates utilizing energy from ATP hydrolysis leading to decreased intracellular drug accumulation and impaired drug efficacy. One treatment strategy might be inhibition of transporter-mediated efflux by small molecules. Isocoumarins and 3,4-dihydroisocoumarins are a large group of natural products derived from various sources with great structural and functional variety, but have so far not been in the focus as potential MDR reversing agents. Thus, three natural products and nine novel 3,4-dihydroisocoumarins were designed and analyzed regarding cytotoxicity induction and inhibition of human ABC transporters P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) in a variety of human cancer cell lines as well as the yeast ABC transporter Pdr5 in Saccharomyces cerevisiae. Dual inhibitors of P-gp and BCRP and inhibitors of Pdr5 were identified, and distinct structure-activity relationships for transporter inhibition were revealed. The strongest inhibitor of P-gp and BCRP, which inhibited the transporters up to 80 to 90% compared to the respective positive controls, demonstrated the ability to reverse chemotherapy resistance in resistant cancer cell lines up to 5.6-fold. In the case of Pdr5, inhibitors were identified that prevented substrate transport and/or ATPase activity with IC50 values in the low micromolar range. However, cell toxicity was not observed. Molecular docking of the test compounds to P-gp revealed that differences in inhibition capacity were based on different binding affinities to the transporter. Thus, these small molecules provide novel lead structures for further optimization.
Water shortage and a rising water demand are prevalent issues on the political agenda worldwide. Available water resources must not only be provided to ensure a domestic and drinking water supply for a steadily increasing population but also for the growing industrial and agricultural sectors. This work outlines how the use of the innovative vacuum multi‐effect membrane distillation contributes to improve the water management efficiency in the following key industry sectors: desalination, drinking water and beverage industry, pharmaceutical, agro and chemical as well as oil and gas industry.