Open Access

Due to its location at the south-west coast of Ireland County (Co.) Cork is frequently affected by post tropical cyclones (PTCs). There have been several records of these post hurricanes in the past with the last severe PTC being Hurricane Ophelia in 2017. It caused severe disruption in the whole country, especially in Co. Cork with several thousand people without water, power and mobile service for up to 10 days and thousands of uprooted trees which blocked roads. PTCs, like Ophelia, will become more frequent under climate change conditions due to warmer sea surface temperatures and decreased vertical wind shear. Hence, hurricanes can reach northern latitudes more easily and have a higher chance of making landfall in Co. Cork. This thesis assesses the risk perception towards natural hazards (NHs) and the perception of the risk communication of hurricane Ophelia by the citizens of Co. Cork and suggests improvements in communication based on the people’s perception. This was achieved by conducting a standardised survey to analyse the perception. The risk communication chain, its content and media involved were evaluated with interviews with professionals involved in risk management in Ireland. Improvement suggestions were extracted of the survey and the expert interviews as well and have been ranked by the participating experts according to their importance. The people of Co. Cork are not overly concerned about being affected by NHs. The three hazards they feel threatened by most, after Ophelia hit the country, are storms, river floodings and hurricanes. Before Ophelia made landfall, they only ranked hurricanes in the 8th place (out of 8). Ergo, after experiencing Ophelia people are much more aware of hurricane risk in Ireland. People were very satisfied with the information they received during Ophelia. The improvements they wished for are: 1) information on how to deal with and how to prepare for impacts of the storm, 2) the impacts that can be expected locally and 3) information where to go to in case of severe impact to property. These are mostly in line with the improvements the experts ranked as most important for Cork. Experts voted the suggestion to include information on behavioural advice into risk communication before the NH hits and advice on how to organise for impacts afterwards as their number one priority. Their second rank is to have education and training for the citizens in Cork. On third place they voted for a change to impact forecasting. Even there are no central buildings or shelters available in Co. Cork, this improvement suggestion was only voted on rank 13 by the experts (out of 14). Having a participatory approach in risk communication can overcome the discrepancies between the wishes of the population and the ones of the experts and would lead to a better understanding of all stakeholders involved in risk communication and can reduce vulnerability of the people in Co. Cork to the impacts of NHs. The implementation of these activities would be in line with best practice examples and would support the guidelines of the Irish Framework for Major Emergency Management.

This study aimed to simulate the sector-coupled energy system of Germany in 2030 with the restriction on CO2 emission levels and to observe how the system evolves with decreasing emissions. Moreover, the study presented an analysis of the interconnection between electricity, heat and hydrogen and how technologies providing flexibility will react when restricting CO2 emissions levels. This investigation has not yet been carried out with the technologies under consideration in this study. It shows how the energy system behaves under different set boundaries of CO2 emissions and how the costs and technologies change with different emission levels. The study results show that the installed capacities of renewable technologies constantly increase with higher limitations on emissions. However, their usage rates decreases with low CO2 emission levels in response to higher curtailed energy. The sector-coupled technologies behave differently in this regard. Heat pumps show similar behaviour, while the electrolysers usage rate increases with more renewable energy penetration. The system flexibility is not primarily driven by the hydrogen sector, but in low CO2 emission level scenarios, the flexibility shifts towards the heating sector and electrical batteries.

Thioredoxin (Trx) overexpression is known to be a cause of chemotherapy resistance in various tumor entities. However, Trx effects on resistance are complex and depend strictly on tissue type. In the present study, we analyzed the impact of the Trx system on intrinsic chemoresistance of human glioblastoma multiforme (GBM) cells to cytostatic drugs. Resistance of GBM cell lines and primary cells to drugs and signaling inhibitors was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Impact of Trx inhibition on apoptosis was investigated by proteome profiling of a subset of proteins and annexin V apoptosis assays. Trx-interacting protein (TXNIP) was overexpressed by transfection and protein expression was determined by immunoblotting. Pharmacological inhibition of Trx by 1-methyl-2-imidazolyl-disulfide (PX-12) reduced viability of three GBM cell lines, induced expression of active caspase-3, and reduced phosphorylation of AKT-kinase and expression of β-catenin. Sensitivity to cisplatin could be restored by both PX-12 and recombinant expression of the upstream Trx inhibitor TXNIP, respectively. In addition, PX-12 also sensitized primary human GBM cells to temozolomide. Combined inhibition of Trx and the phosphatidylinositide 3-kinase (PI3K) pathway resulted in massive cell death. We conclude that the Trx system and the PI3K pathway act as a sequential cascade and could potentially present a new drug target.

Abstract (−)‐Menthol is one of the most popular aroma compounds worldwide. While in the past mostly extracted from mint plants, today (−)‐menthol synthesis from other raw materials is becoming more relevant. Common starting materials for menthol synthesis are m‐cresol, citral and myrcene, but also substrates like menthone, mono‐ and bicyclic terpenes and terpenoids have been used for this purpose in the past. As for many applications (−)‐menthol of high purity is required, asymmetric syntheses and enantiomeric resolution of obtained raw products are applied for menthol production. This review gives an overview on the most important synthetic menthol production processes of the companies Symrise, Takasago and BASF and relevant literature in the field of menthol synthesis with a focus on the last 20 years.

Air-blast loading is a serious threat to military and civil vehicles, buildings, containers, and cargo. Applications of sandwich-structured composites have attracted increasing interest in modern lightweight design and in the construction of dynamic loading regimes due to their high resistance against blast and ballistic impacts. The functional properties of such composites are determined by the interplay of their face sheet material and the employed core topology. The core topology is the most important parameter affecting the structural behavior of sandwich composites. Therefore, this contribution presents a thorough numerical investigation of different core topologies in sandwich-structured composites subjected to blast loading. Special emphasis is put on prismatic and lattice core topologies displaying auxetic and classical non-auxetic deformation characteristics in order to illustrate the beneficial properties of auxetic core topologies. Their dynamic responses, elastic and plastic deformations, failure mechanisms, and energy absorption capabilities are numerically analyzed and compared. The numerical studies are performed by means of the commercial finite element code ABAQUS/Explicit, including a model for structural failure.