600 Technik, Medizin, angewandte Wissenschaften
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This paper documents the design, implementation and evaluation of the Unfolding Space Glove—an open source sensory substitution device. It transmits the relative position and distance of nearby objects as vibratory stimuli to the back of the hand and thus enables blind people to haptically explore the depth of their surrounding space, assisting with navigation tasks such as object recognition and wayfinding. The prototype requires no external hardware, is highly portable, operates in all lighting conditions, and provides continuous and immediate feedback—all while being visually unobtrusive. Both blind (n = 8) and blindfolded sighted participants (n = 6) completed structured training and obstacle courses with both the prototype and a white long cane to allow performance comparisons to be drawn between them. The subjects quickly learned how to use the glove and successfully completed all of the trials, though still being slower with it than with the cane. Qualitative interviews revealed a high level of usability and user experience. Overall, the results indicate the general processability of spatial information through sensory substitution using haptic, vibrotactile interfaces. Further research would be required to evaluate the prototype’s capabilities after extensive training and to derive a fully functional navigation aid from its features.
Im Rahmen des Technologie-Screenings wurden smarte Technologien für den Einsatz in mittelständischen Unternehmen (vorzugsweise KMU) im Zeitraum von 2017-2020 in einem kontinuierlichen Monitoringprozess betrachtet. Dadurch konnte mit dem Screening ein umfassender Überblick über die Angebotsseite und den Markt smarter Technologien geschaffen werden. Ebenso wurden potenzielle Technologien für den Einsatz im Anwendungstest des Forschungsprojekts VISE-U identifiziert. Insgesamt umfasst das Technologie-Screening sechs spezifische Technologie-Kategorien, denen wiederum einzelne Systeme auf Herstellerebene zugeordnet wurden. So konnten in Summe 20 Systeme unterschiedlicher Hersteller hinsichtlich des Aufbaus sowie der Funktionsweise samt Technologie-Steckbrief beschrieben werden. Die Steckbriefe zeigen dazu die technische Beschreibung, Komponenten sowie Schnittstellen der Systeme auf und referenzieren auf weiterführende Informationen auf den Webseiten der Hersteller.
Im Rahmen des Technologiescreenings sind zunächst relevante Technologien, die Einfluss auf das Energienachfrageverhalten für Haushalte besitzen, identifiziert worden. Dabei ist ausschließlich eine technologische Betrachtung erfolgt, das individuelle Nutzerverhalten von Haushaltsbewohnern wurde dabei nicht betrachtet. Die Einordnung der Technologien sind in Standard Energietechnologien: Erzeuger, Umwandler, Verbraucher und Speicher kategorisiert. Zudem zeigt die in die Kategorien Messsysteme, Gebäudeautomation und Energiemanagementsysteme. Dabei handelt es sich um, digitale Technologien mit Aspekten und Anwendungen von Energietransparenz und -management. Zeitraum des kontinuierlichen Technologie-Screenings war von 2017-2020.
Die Dimensionierung von thermischen Speichern in der Gebäudetechnik bezieht sich häufig auf die Trinkwassererwärmung mit der DIN 4708. Dabei werden in der Regel die Bedarfe der Nutzer zur Auslegung herangezogen. Bekannt ist das Summenlinienverfahren und der daraus resultierende Beitrag des Wärmeerzeugers. Bei Pufferspeichern wird dagegen unter-schieden in welcher Kombination von Speicher und Wärmerzeuger dieser eingesetzt werden soll und es kommt häufig zu Größenschätzungen und Auslegungen mit Richtwerten. Daneben bieten zahlreiche Herstellern Auslegungsprogramme, die immer auf den Spitzenbedarf des Gebäudes ausgelegt sind.
In diesem Beitrag wird eine Methode vorgestellt, die den thermischen Speicher als zweiten Wärmeversorger im Gebäude betrachtet, der zusammen mit diesem die Versorgung über-nimmt. Damit wird die Speicherauslegung mit der Wärmeerzeugerleistung verknüpft. Aus-gleichend über eine bestimmte Zeitperiode (24 h) mit Phasen hohen und niedrigen Bedarfs übernehmen der Wärmeerzeuger und der Speicher gemeinsam die Versorgung. Da die Wärmeversorgung eines Gebäudes in erster Linie von der Außenlufttemperatur abhängt, wird hier ein Verfahren auf dieser Basis vorgestellt, welches eine einfache Berechnung des Wärmeinhalts eines Speichers ermöglicht.
Das interdisziplinäre Forschungsprojekt “Smarte Technologien für Unternehmen” untersuchte im Zeitraum von Juli 2017 bis Dezember 2020 Anwendungs- und Akzeptanzprobleme zum Einsatz smarter Technologien in KMU und entwickelte darauf aufbauend Lösungsansätze zur Steigerung der Energieeffizienz sowie zum Energie- und Lastmanagement. Dazu wurden smarte Technologien zunächst im Zuge eines Screenings identifiziert, kategorisiert und bewertet. In den qualitativen und quantitativen Nutzeranalysen wurden Unternehmer*innen in den Fokus der Analyse gestellt, um den Wissensstand sowie Chancen und Barrieren zum Einsatz smarter Technologien in KMU darzulegen. Mit der Durchführung transdisziplinärer Anwendungstests wurde ein zentraler Lösungsansatz entwickelt: Die Effizienzanalyse von KMU mittels mobiler Messtechnik und Visualisierungstools als potenzielle Strategie zur Reduktion von Energieverbräuchen.
Die Ergebnisse dieses anwendungsorientierten Forschungsprojektes zeigen die Anwendungs- und Akzeptanzprobleme zum Einsatz smarter Technologien in KMU auf und geben Handlungsoptionen zur Steigerung der Energieeffizienz mit Hilfe ausgewählter smarter Produkte und Tools.
New risk geographies are emerging with war and conflict resurfacing, including nuclear threats. This poses challenges to civil protection for conducting risk-informed preparedness planning. A spatial assessment of Germany and Europe is conducted using a geographic information system. Buffer circles of nuclear explosion effects and fallout buffers show potentially exposed areas around major cities. Different scenarios indicate shrinking areas safe from exposure. However, even in a densely populated country, rural areas and smaller cities can be identified that could provide sites for evacuation shelters. Changing wind directions poses a challenge for civil protection planning because fallout risk covers most German territory even when few cities are attacked. However, wind speeds and topography can help identify suitable shelter areas. More knowledge about the temporal development of a nuclear explosion and its specific forms of harm can also help to improve risk knowledge and planning. While nuclear warfare at first seems to render useless any option for safe areas and survival, the spatial risk assessment shows that exposure does not occur at all places at all times. Being safe from harm will be difficult in such a worst-case scenario, but avoiding large city perimeters and being informed can also help reduce risk.
Pressure injuries remain a serious health complication for patients and nursing staff. Evidence from the past decade has not been analysed through narrative synthesis yet. PubMed, Embase, CINAHL Complete, Web of Science, Cochrane Library, and other reviews/sources were screened. Risk of bias was evaluated using a slightly modified QUIPS tool. Risk factor domains were used to assign (non)statistically independent risk factors. Hence, 67 studies with 679,660 patients were included. In low to moderate risk of bias studies, non-blanchable erythema reliably predicted pressure injury stage 2. Factors influencing mechanical boundary conditions, e.g., higher interface pressure or BMI < 18.5, as well as factors affecting interindividual susceptibility (male sex, older age, anemia, hypoalbuminemia, diabetes, hypotension, low physical activity, existing pressure injuries) and treatment-related aspects, such as length of stay in intensive care units, were identified as possible risk factors for pressure injury development. Health care professionals’ evidence-based knowledge of above-mentioned risk factors is vital to ensure optimal prevention and/or treatment. Openly accessible risk factors, e.g., sex, age, BMI, pre-existing diabetes, and non-blanchable erythema, can serve as yellow flags for pressure injury development. Close communication concerning further risk factors, e.g., anemia, hypoalbuminemia, or low physical activity, may optimize prevention and/or treatment. Further high-quality evidence is warranted.
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a requirement for successful therapy, which is frequently not possible due to the lack of suitable dosage forms. For precision medicine, individual characteristics of patients are considered for the selection of the best possible API in the most suitable dose with the most effective release profile to improve therapeutic outcome. 3d printing is inherently suitable for manufacturing of individualized medicines with varying dosages, sizes, release profiles and drug combinations in small batch sizes, which cannot be manufactured with traditional technologies. However, understanding of critical quality attributes and process parameters still needs to be significantly improved for this new technology. To ensure health and safety of patients, cleaning and process validation needs to be established. Additionally, adequate analytical methods for the in-process control of intermediates, regarding their printability as well as control of the final 3d printed tablets considering any risk of this new technology will be required. The PolyPrint consortium is actively working on developing novel polymers for fused deposition modeling (FDM) 3d printing, filament formulation and manufacturing development as well as optimization of the printing process, and the design of a GMP-capable FDM 3d printer. In this manuscript, the consortium shares its views on quality aspects and measures for 3d printing from drug-loaded filaments, including formulation development, the printing process, and the printed dosage forms. Additionally, engineering approaches for quality assurance during the printing process and for the final dosage form will be presented together with considerations for a GMP-capable printer design.
Despite great efforts to develop a vaccine against human immunodeficiency virus (HIV), which causes AIDS if untreated, no approved HIV vaccine is available to date. A promising class of vaccines are virus-like particles (VLPs), which were shown to be very effective for the prevention of other diseases. In this study, production of HI-VLPs using different 293F cell lines, followed by a three-step purification of HI-VLPs, was conducted. The quality-by-design-based process development was supported by process analytical technology (PAT). The HI-VLP concentration increased 12.5-fold while >80% purity was achieved. This article reports on the first general process development and optimization up to purification. Further research will focus on process development for polishing and formulation up to lyophilization. In addition, process analytical technology and process modeling for process automation and optimization by digital twins in the context of quality-by-design framework will be developed.
Potential analyses identify possible locations for renewable energy installations, such as wind turbines and photovoltaic arrays. The results of previous potential studies for Germany, however, are not consistent due to different assumptions, methods, and datasets being used. For example, different land-use datasets are applied in the literature to identify suitable areas for technologies requiring open land. For the first time, commonly used datasets are compared regarding the area and position of identified features to analyze their impact on potential analyses. It is shown that the use of Corine Land Cover is not recommended as it leads to potential area overestimation in a typical wind potential analyses by a factor of 4.7 and 5.2 in comparison to Basis-DLM and Open Street Map, respectively. Furthermore, we develop scenarios for onshore wind, offshore wind, and open-field photovoltaic potential estimations based on land-eligibility analyses using the land-use datasets that were proven to be best by our pre-analysis. Moreover, we calculate the rooftop photovoltaic potential using 3D building data nationwide for the first time. The potentials have a high sensitivity towards exclusion conditions, which are also currently discussed in public. For example, if restrictive exclusions are chosen for the onshore wind analysis the necessary potential for climate neutrality cannot be met. The potential capacities and possible locations are published for all administrative levels in Germany in the freely accessible database (Tool for Renewable Energy Potentials—Database), for example, to be incorporated into energy system models.